|
KMID : 0620920170490090006
|
|
Experimental & Molecular Medicine
2017 Volume.49 No. 9 p.6 ~ p.6
|
|
|
A focus on extracellular Ca2+ entry into skeletal muscle
|
|
Cho Chung-Hyun
Woo Jin-Seok
Perez Claudio F.
Lee Eun-Hui
|
|
|
Abstract
|
|
|
|
The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca2+ in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca2+ level is mainly determined by Ca2+ movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca2+ entry from extracellular spaces to the cytosol has gained significant attention over the past decade. Store-operated Ca2+ entry with a low amplitude and relatively slow kinetics is a main extracellular Ca2+ entryway into skeletal muscle. Herein, recent studies on extracellular Ca2+ entry into skeletal muscle are reviewed along with descriptions of the proteins that are related to extracellular Ca2+ entry and their influences on skeletal muscle function and disease.
|
|
|
KEYWORD
|
|
|
Diseases, Physiology
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|